Resource Library

Glossary

A practical vocabulary for molecular allergology education and multidisciplinary discussion.

Allergen component

A defined allergenic molecule within an allergen source, such as a specific protein from peanut, birch pollen, house dust mite, or grass pollen.

Component-resolved diagnostics

An approach that measures IgE sensitisation to individual allergen molecules rather than only whole allergen extracts.

Cross-reactivity

Recognition of similar molecular structures across different allergen sources, which may or may not reflect clinically relevant allergy.

Genuine sensitisation

A sensitisation pattern suggesting primary immune recognition of an allergen source rather than a cross-reactive marker alone.

Panallergen

A broadly distributed allergen family that can appear across many biological sources and contribute to multiple positive results.

Risk stratification

The process of estimating clinical relevance and potential severity using history, exposure, test patterns, and specialist judgement.

Storage proteins

Relatively stable food allergen families often discussed in relation to systemic reactions and persistent food allergy patterns.

PR-10 proteins

A plant protein family often associated with pollen-food patterns, especially where birch pollen sensitisation is relevant.

Profilin

A highly cross-reactive plant protein family that can contribute to broad sensitisation patterns across pollens and foods.

Polcalcin

A calcium-binding pollen panallergen family that may contribute to broad pollen sensitisation patterns.

nsLTP

Non-specific lipid transfer proteins are relatively stable plant food allergens that may be relevant to systemic reactions in some clinical contexts.

Tropomyosin

A cross-reactive invertebrate muscle protein family relevant to interpretation across shellfish, mite, cockroach, and parasite-related sensitisation.

CCD

Cross-reactive carbohydrate determinants are carbohydrate structures that may cause broad in vitro IgE reactivity with variable clinical relevance.

Top-down approach

A diagnostic strategy that starts with symptoms and suspected sources, then uses molecular testing to refine interpretation.

Bottom-up approach

A strategy that starts with broad molecular results, then maps the sensitisation pattern back to the clinical story.